The　performance　of　metal　sites　in　terms　of　their　formation,　evolution,　and　deactivation　is　strongly　influenced　by　the　properties　of　the　supports　during　catalysis.　Nanomaterials　offer　a　tailorable　size,　shape,　and　composition,　along　with　a　large　surface　area,　a　high　fraction　of　surface　atoms,　and　unique　electronic　properties,　thereby　significantly　improving　the　efficiency,　selectivity,　stability,　and　versatility　of　catalytic　processes.　In　the　direct　dehydrogenation　of　propane　(PDH)　reactions,　the　activity,　selectivity,　and　durability　of　catalysts　face　challenges　due　to　the　high　reaction　temperature　and　harsh　atmosphere　that　accompanies　the　presence　of　reducible　reactants.　Herein,　bimetallic　platinum-zinc　(PtZn)　sites　were　synthesized　on　various　silica　nanomaterials　to　investigate　the　correlation　between　the　nanoscale　properties　of　silica　and　PDH　performance.　Among　the　supports　being　explored,　including　amorphous　SiO2　particles,　mesoporous　SBA-15,　microporous　silicate-1,　and　mesoporous　MCM-41,　MCM-41　stood　out　due　to　its　distinctive　advantages,　including　a　large　specific　surface　area,　well-portioned　pore　size　and　distribution,　and　an　appropriate　amount　and　strength　of　acidic　sites.　Operating　at　a　temperature　of　600　degrees　C,　the　catalyst　exhibited　a　notable　propene　production　rate　of　approximately　37.3　mmolg(cat)(-1)h(-1).　This　performance　was　coupled　with　an　outstanding　initial　conversion　(39.2%)　and　selectivity　(97.7%)　during　the　PDH　reaction.　The　characterization　results　highlighted　the　exceptional　dispersion　of　the　PtZn　sites　on　the　MCM-41　support,　showing　remarkable　resistance　to　coking　and　sintering　throughout　the　reaction.　These　attributes　exceeded　those　observed　in　other　silica　supports.