The　efficacy　of　chemodynamic　therapy　(CDT)　and　its　potential　to　induce　immunogenic　cell　death　(ICD)　are　highly　dependent　on　the　types　and　efficiency　of　generated　reactive　oxygen　species　(ROS).　Herein,　we　innovatively　develop　a　manganese　platinum　(MnPt)　nanozyme　with　dual　ROS　generation　for　magnetic　resonance　imaging　guided　CDT　and　ICD.　The　multivalence　state　of　Mn　ions　authorizes　MnPt　to　simultaneously　generate　hydroxyl　radical　and　singlet　oxygen　under　high　H2O2　and　acid　condition,　which　obviously　increases　the　types　of　ROS.　Significantly,　the　mild　photothermal　conversion　and　enzyme-like　activity　endow　MnPt　to　regulate　tumor　microenvironment　and　elevate　the　operating　rate,　further　increasing　the　ROS　generation　efficiency　and　CDT　efficacy　in　vitro/vivo.　Moreover,　the　exaltation　on　both　types　and　generation　efficiency　of　ROS　significantly　enhances　immunogenicity　and　initiates　the　immune　response　to　limit　tumor　metastases.　This　study　provides　a　highly　practical　strategy　for　the　accurate　diagnosis　and　efficient　therapy　of　tumors.　©　2024　American　Chemical　Society.