For　the　most　commonly　applied　platinum-based　catalysts　of　direct　methanol　fuel　cells,　the　adsorption　ability　toward　reaction　intermediates,　including　CO　and　OH,　plays　a　vital　role　in　their　catalytic　activity　and　antipoisoning　in　anodic　methanol　oxidation　reaction　(MOR).　Herein,　guided　by　a　theoretical　mechanism　study,　a　favorable　modulation　of　the　electronic　structure　and　intermediate　adsorption　energetics　for　Pt　active　sites　is　achieved　by　constructing　the　triple-phase　interfacial　structure　between　tin　oxide　(SnO2),　platinum　(Pt),　and　nitrogen-doped　graphene　(NG).　From　the　strong　electronic　exchange　at　the　triple-phase　interface,　the　adsorption　ability　toward　MOR　reaction　intermediates　on　Pt　sites　could　be　efficiently　optimized,　which　not　only　inhibits　the　adsorption　of　CO*　on　active　sites　but　also　facilitates　the　adsorption　of　OH*　to　strip　the　poisoning　species　from　the　catalyst　surface.　Accordingly,　the　resulting　catalyst　delivers　excellent　catalytic　activity　and　antipoisoning　ability　for　MOR　catalysis.　The　mass　activity　reaches　1098　mA　mg-1Pt,　3.23　times　of　commercial　Pt/C.　Meanwhile,　the　initial　potentials　and　main　peak　for　CO　oxidation　are　also　located　at　a　much　lower　potential　(0.51　and　0.74　V)　against　commercial　Pt/C　(0.83　and　0.89　V).　©　2024　American　Chemical　Society.