Implant-associated　infections　due　to　the　formation　of　bacterial　biofilms　pose　a　serious　threat　in　medical　healthcare,　which　needs　effective therapeutic　methods.　Here,　we　propose　a　multifunctional nanoreactor　by　spatiotemporal　ultrasound-driven　tandem　catalysis　to amplify　the　efficacy　of sonodynamic　and　chemodynamic　therapy.　By　combining　piezoelectric　barium　titanate　with　polydopamine　and　copper,　the　ultrasound-activated　piezo-hot　carriers　transfer　easily　to　copper　by　polydopamine.　It　boosts　reactive　oxygen　species　production　by　piezoelectrics,　and　facilitates　the　interconversion　between　Cu2+　and　Cu+　to　promote　hydroxyl　radical　generation　via　Cu+　-catalyzed　chemodynamic　reactions.　Finally,　the　elevated　reactive　oxygen　species　cause　bacterial　membrane　structure　loosening　and　DNA　damage.　Transcriptomics　and　metabolomics　analysis　reveal　that　intracellular　copper　overload　restricts　the　tricarboxylic　acid　cycle,　promoting　bacterial　cuproptosis-like　death.　Therefore,　the　polyetherketoneketone　scaffold　engineered　with　the　designed　nanoreactor　shows　excellent　antibacterial　performance　with　ultrasound　stimulation　and　promotes　angiogenesis　and　osteogenesis　on-demand　in　vivo.　©　The　Author(s)　2024.