Dimethylfuran　is　a　promising　liquid　fuel　that　can　be　derived　from　sustainable　biomass　sources.　Obtaining　dimethylfuran　from　biomass　through　an　efficient　catalytic　hydrodeoxygenation　process　is　an　effective　way　to　achieve　carbon　neutrality.　Herein,　we　report　a　catalytic　system　employing　a　highly　dispersed　Pd-Co　bimetallic　catalyst　supported　on　molybdenum　carbide　for　the　conversion　of　5-hydroxymethylfurfural　to　dimethylfuran.　Bimetallic　catalysts　with　varying　Co　loading　were　prepared　via　co-precipitation　and　temperature-programmed　carburization,　followed　by　a　series　of　hydrodeoxygenation　performance　evaluation.　The　results　reveal　that,　at　180　°C　and　2　MPa　hydrogen　pressure,　the　0.5Pd10Co/MoCx　catalyst　achieves　a　remarkable　5-hydroxymethylfurfural　conversion　of　99.9　%　with　a　dimethylfuran　selectivity　exceeding　97　%.　Comprehensive　characterizations　confirm　the　role　of　bimetallic　active　sites　and　suggest　the　reaction　mechanism.　Pd　doping　enhances　the　surface　area　and　promotes　hydrogen　dissociation,　and　consequently　lowering　the　reduction　temperature　of　catalyst.　The　unique　electronic　structure　of　Mo　in　the　carbide　support　promotes　charge　transfer　from　the　support　to　the　Pd-Co　bimetallic　site,　thereby　promoting　the　generation　of　more　Coδ+　and　Co2+.　The　presence　of　a　high　oxygen　vacancy　content　facilitates　the　cleavage　of　C-O　bonds,　while　the　synergy　effect　of　bimetallic　sites　changes　the　reaction　path　and　promotes　the　hydrogenation　of　the　aldehyde　group,　thus　greatly　improving　the　reaction　efficiency.　©　2023　Elsevier　Ltd