Combining　a　traditional　mixer　and　a　custom-built　ultrasonic　generator,　low-temperature　green　regeneration　of　waste　rubber　was　realized.　Through　orthogonal　experiments,　the　optimal　process　parameters　for　the　low-temperature　green　regeneration　through　the　ultrasound-assisted　(LTGRTUA)　method　were　explored.　Results　showed　that　the　self-developed　reclaimed　rubber　exhibited　the　best　performance　under　the　following　conditions:　rotor　speed　of　70　rpm,　regeneration　temperature　of　85°C,　ultrasonic　power　of　700　W,　and　ultrasonic　loading　time　of　240　s.　Additionally,　the　bond-breaking　types　of　the　reclaimed　rubber　were　evaluated　through　the　measurements　of　sol　fraction　and　desulfurization　rate,　as　well　as　by　using　the　Horikx　curve.　The　self-developed　reclaimed　rubber　showed　better　retention　of　the　main　chain　structure　of　waste　rubber　compared　to　the　commercially　reclaimed　rubber　which　was　prepared　by　the　traditional　vulcanization　tank　high-temperature　regeneration　(TVTHTR)　method.　Moreover,　blending　experiments　were　conducted,　in　which　different　proportions　of　the　reclaimed　rubber　replaced　natural　rubber　(NR)　for　the　purpose　of　producing　tread　rubber　for　radial　tires.　Performance　tests　of　the　final　products　revealed　that　the　self-developed　reclaimed　rubber　performed　better　than　commercially　reclaimed　rubber,　which　provides　an　effective　basis　for　the　subsequent　industrial　application　and　promotion.　Highlights:　Low-temperature　green　regeneration　of　waste　rubber　was　realized　by　the　LTGRTUA　method.　The　main　chain　structure　of　waste　rubber　is　well　preserved　by　the　LTGRTUA　method.　The　self-developed　reclaimed　rubber　has　better　properties　and　industrial　application　prospects.　©　2023　Society　of　Plastics　Engineers.