A　general　domino　annulation　reaction　of　sulfonylmethyl　isocyanide　with　trifluoroacetic　anhydride　in　the　presence　of　copper　chloride　as　an　additive　is　developed.　The　reaction　affords　2,5-bis(trifluoromethyl)oxazoles　in　modest　to　good　yields　under　mild　conditions.　A　wide　variety　of　sulfonylmethyl　isocyanide　and　perfluorocarboxylic　anhydride　substrates　are　amenable　to　this　transformation.　Under　a　higher　copper　salt　loading　conditions,　the　reaction　led　to　the　formation　of　monotrifluoromethyl-substituted　oxazole　product.