Application of Caco-2 Cell Model to Transportation and Absorption of Toxic Substances - Details

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SCIE PKU CSCD

Abstract：

The　Caco-2　cell　monolayer,　isolated　from　human　colon　carcinoma,　has　been　wildly　used　in　toxicology　study　and　used　as　a　tool　to　study　the　intestinal　uptake　and　transport　processes　of　xenobiotic.　We　introduces　the　culture　conditions,　the　basic　characteristics　and　functional　parameters　of　Caco-2　cell　monolayer　model　in　brief.　The　paper　also　discussed　the　application　of　Caco-2　cell　monolayer　model　in　studying　the　mechanism　of　intestinal　transportation　and　absorption　of　environmental　toxic　substances　and　toxic　effects　of　these　substances　on　their　intestinal　transportation　and　absorption　in　detail.　In　addition,　the　application　of　Caco-2　cells　in　human　health　risk　assessment　for　environmental　toxic　substances　is　prospected.

Keyword：

bioavailability Caco-2 cells environmental risk assessment in vitro test toxic substances transportation and absorption

Community：

[ 1 ] [Wang Deqing]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 2 ] [Yu Yingxin]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 3 ] [Zhong Yufang]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 4 ] [Wu Minghong]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 5 ] [Sheng Guoying]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 6 ] [Fu Jiamo]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China
[ 7 ] [Sheng Guoying]Chinese Acad Sci, State Key Lab Organ Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou Inst Geochem, Guangzhou 510640, Peoples R China
[ 8 ] [Fu Jiamo]Chinese Acad Sci, State Key Lab Organ Geochem, Guangdong Key Lab Environm Resources Utilizat & P, Guangzhou Inst Geochem, Guangzhou 510640, Peoples R China

Reprint 's Address：

Email：

mhwu@shu.edu.cn

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Source ：

PROGRESS IN CHEMISTRY

ISSN： 1005-281X

CN： 11-3383/O6

Year： 2010

Issue： 4

Volume： 22

Page： 740-747

0 . 5 6

JCR@2010

1 . 0 0 0

JCR@2023

JCR Journal Grade：4

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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