In　this　study,　a　series　of　mesoporous　silica　nanoparticles　(MSNs)　with　well-defined　morphologies　and　diverse　pore　structures　have　been　successfully　fabricated　under　alkaline　conditions.　In　this　case,　cetyltrimethylammonium　bromide　(CTAB)　was　employed　as　the　structure-directing　agent,　ethylacetate　(EA)　as　the　co-template,　ethanol　and　water　as　co-solvents.　By　simply　tuning　the　volume　of　ethanol　in　the　reaction　precursor,　the　trilobite-like　nanoparticles,　unique　nanospheres　with　parallel　and　radical　pores,　and　worm-like　pore　structure　nanoparticles　were　obtained.　The　silica　nanostructures　were　characterized　by　transmission　electron　microscopy　(TEM),　scanning　electron　microscopy　(SEM),　X-ray　diffraction　(XRD),　N-2　adsorption-desorption　measurement,　etc.　During　the　synthesis　process,　the　lamellar　micelles　and　microemulsion　droplets　formed　in　an　oil-water　(O/W)　mixture　played　a　key　role　for　the　formation　of　diverse　MSNs.　Additionally,　the　as-prepared　MSNs　showed　good　biocompatibility　and　high　drug　storage　capability　for　ibuprofen　(IBU)　loading.　More　importantly,　when　used　as　a　nanoreactor　for　constructing　the　novel　functionalized　Au@MSNs　nanocomposites,　they　exhibited　superior　catalytic　activities　for　the　reduction　of　4-nitrophenol　(4-NP).　The　present　findings　could　provide　more　possibilities　for　the　controllable　fabrication　of　silica　nanomaterials　and　their　potential　applications.