Catalysts　are　essential　in　the　catalytic　oxidation　technology　for　VOCs　treatment.　In　the　actual　conditions　of　VOCs　degradation,　the　composition　of　industrial　flue　gas　is　complex,　which　seriously　affects　the　structure　and　activity　of　the　catalysts,　and　this　effect　can　be　either　positive　or　negative.　Therefore,　this　paper　reviews　the　research　progress　in　the　catalytic　oxidation　of　VOCs　in　the　simulated　flue　gas　in　recent　years,　focusing　on　the　effects　of　different　components　of　flue　gas　on　the　structure　and　activity　of　catalysts.　Firstly,　the　effects　of　water,　SO2,　NOx,　Cl,　CO2,　and　heavy　metals　in　the　actual　industrial　flue　gas　on　the　structure　and　performance　of　the　catalyst　are　discussed,　including　the　promoting　and　inhibiting　effects.　Then,　according　to　the　different　components　in　the　flue　gas,　the　methods　to　improve　the　antitoxicity　of　the　catalyst　are　reviewed　in　detail.　Finally,　the　current　research　status　is　summarized,　and　the　challenges　and　prospects　of　antitoxicity　catalysts　for　VOCs　are　proposed.　This　work　aims　to　provide　a　theoretical　and　experimental　basis　for　the　rational　preparation　of　VOCs　catalysts　with　superb　antitoxicity　in　industry.