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author:

Li, J. (Li, J..) [1] | Jiang, Y. (Jiang, Y..) [2] | Xu, A. (Xu, A..) [3] | Luo, F. (Luo, F..) [4] | Lin, C. (Lin, C..) [5] | Qiu, B. (Qiu, B..) [6] | Lin, Z. (Lin, Z..) [7] | Jiang, Z. (Jiang, Z..) [8] | Wang, J. (Wang, J..) [9]

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Scopus

Abstract:

In recent years, the development of miniature and portable sensors has been a major focus of research. PEC self-powered sensors have emerged as a potential solution to the power supply issue, eliminating the need for external power supplies and operating without bias voltage. This study developed a ZnO/Au/GaN sensor for highly sensitive detection of alpha-fetoprotein (AFP). The sensor uses GaN substrates with nanogold films to provide an auxiliary bias voltage, promoting high photogenerated current density. Using ZnO/Au/GaN as a photoanode resulted in significantly higher photocurrent generated by the sensor compared to Au/GaN or ZnO/ITO alone. To enable selective detection of AFP, antibody modification of the ZnO nanorod arrays was employed. The linear range of the sensor response to AFP was determined to be 0.080–5.0 ng/mL, with an impressively low detection limit of 0.027 ng/mL (S/N = 3). These results demonstrate the potential of this self-powered sensor for detecting AFP content in human serum samples. Overall, this study presents a novel approach for developing highly sensitive and selective self-powered sensors for biomarker detection, which could facilitate early detection and clinical diagnosis of various types of cancer. © 2023 Elsevier B.V.

Keyword:

Alpha-fetoprotein GaN Photoelectrochemical sensor ZnO

Community:

  • [ 1 ] [Li J.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 2 ] [Li J.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 3 ] [Jiang Y.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 4 ] [Jiang Y.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 5 ] [Xu A.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 6 ] [Xu A.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 7 ] [Luo F.]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 8 ] [Lin C.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 9 ] [Qiu B.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 10 ] [Qiu B.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 11 ] [Lin Z.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 12 ] [Lin Z.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 13 ] [Jiang Z.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 14 ] [Wang J.]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 15 ] [Wang J.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China

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Talanta

ISSN: 0039-9140

Year: 2024

Volume: 268

5 . 6 0 0

JCR@2023

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 7

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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