The　dead-end　anode　(DEA)　mode　effectively　improves　hydrogen　utilization　rate　of　high-temperature　proton　exchange　membrane　fuel　cell　(HT-PEMFC).　However,　being　in　DEA　mode　for　a　long　time　can　lead　to　hydrogen　starvation　in　HT-PEMFC　and　reduce　its　performance.　This　study　aims　to　reduce　the　adverse　effects　of　DEA　on　HTPEMFC　by　setting　up　appropriate　operating　conditions.　A　novel　transient　model　of　HT-PEMFC　was　successfully　developed　by　considering　gas　crossover　phenomena.　The　paper　evaluates　the　effects　of　key　operating　parameters,　geometric　parameters,　and　gas　crossover　phenomena　on　the　transient　performance　of　HT-PEMFC　in　DEA　mode.　The　results　show　that　the　performance　deterioration　over　time　during　the　DEA　process　varies　under　different　operating　conditions.　The　amount　of　hydrogen　and　oxygen　crossover　decrease　significantly　with　the　increase　of　membrane　thickness.　In　DEA　mode,　the　performance　of　HT-PEMFC　decreases　with　increasing　of　water　vapor　transport　coefficient;　when　the　anode　is　open,　the　comprehensive　performance　of　medium　water　vapor　transport　coefficient　is　the　best.　This　work　can　provide　a　suitable　working　condition　scheme　to　reduce　the　adverse　effects　of　DEA　on　HT-PEMFC.