Background:　The　accumulation　of　antibiotics　in　water　systems　has　received　considerable　global　attention　due　to　its　detrimental　effects.　There　is　an　urgent　need　to　develop　rapid　and　efficient　methods　for　the　degradation　of　antibiotics.Methods:　In　this　work,　a　highly　efficient　AgFeO2/Ag3VO4　photocatalyst　was　successfully　fabricated　by　a　hydrothermal　method　and　analyzed　using　different　techniques.　Under　visible　light　irradiation,　photocatalytic　behavior　of　AgFeO2/Ag3VO4　heterojunctions　in　the　degradation　of　levofloxacin　is　investigated.　Significant　findings:　The　results　showed　that　p-n　heterojunction　was　formed　between　AgFeO2　and　Ag3VO4,　which　improved　the　separation　and　transfer　of　photogenerated　charge　carrier　under　the　action　of　the　internal　electric　field.　The　apparent　reaction　rate　of　AgFeO2/Ag3VO4　heterostructure　toward　degradation　of　levofloxacin　reached　to　0.2770　min-1,　which　was　about　2.15　times　and　36.73　times　larger　than　those　of　Ag3VO4　and　AgFeO2,　respectively,　and　much　larger　than　other　counterparts.　Furthermore,　possible　photocatalytic　degradation　pathway　of　levofloxacin　was　comprehensively　determined　by　LC-MS　analysis.　This　work　would　provide　in-depth　understanding　on　the　efficient　photocatalytic　removal　of　antibiotics　for　sustainable　environmental　remediation.