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author:

Zhou, Yao (Zhou, Yao.) [1] | Chen, Fuling (Chen, Fuling.) [2] | Li, Ziru (Li, Ziru.) [3] | Dong, Junjie (Dong, Junjie.) [4] | Li, Jingnan (Li, Jingnan.) [5] | Zhang, Bohao (Zhang, Bohao.) [6] | Song, Qiuling (Song, Qiuling.) [7]

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Abstract:

A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein. Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol, facilitating the cleavage of the N−N bond via carbon atom insertion. This metal-free ring expansion reaction enables the late-stage diversification of indazole skeletons, assembling a diverse array of functionalized quinazolin-4(3H)-ones in decent yields with excellent functional group compatibility. [Figure not available: see fulltext.] © 2023, Science China Press.

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Atoms

Community:

  • [ 1 ] [Zhou, Yao]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 2 ] [Chen, Fuling]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 3 ] [Li, Ziru]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 4 ] [Dong, Junjie]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 5 ] [Li, Jingnan]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 6 ] [Zhang, Bohao]Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi; 435002, China
  • [ 7 ] [Song, Qiuling]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fuzhou; 350108, China

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Science China Chemistry

ISSN: 1674-7291

Year: 2023

Issue: 7

Volume: 66

Page: 1975-1981

1 0 . 4

JCR@2023

1 0 . 4 0 0

JCR@2023

ESI HC Threshold:39

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 27

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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