The　traditional　fire　alarm　sensors　suffer　from　sluggish　fire　warnings.　Recently,　graphene　oxide　(GO)-based　sensors　have　attracted　much　attention　due　to　their　ultrafast　fire　warning.　There　are　two　major　challenges:　(i)　the　duration　time　of　fire　warning　is　short　due　to　poor　flame　retardancy　of　GO　and　(ii)　the　response　temperature　of　the　GO　sensor　is　high　due　to　the　abundant　oxygen-containing　groups.　This　work　reports　the　single-stranded　deoxyribonucleic　acid　(ssDNA)-modified　GO　supported　on　the　hydroxyapatite　(HA)　nanowire　paper.　The　ssDNA　molecules　have　an　action　of　intumescent　flame　retardancy,　which　effectively　improves　the　flame　retardancy　of　GO.　Moreover,　the　thermal　degradation　of　nitrogenous　base　of　ssDNA　causes　nitrogen　doping　in　GO.　Concomitantly,　the　thermal　reduction　of　GO　is　promoted,　and　some　oxidative　groups　are　removed.　As　a　result,　the　period　of　fire　warning　of　GO　increases　up　to　180　s,　and　the　response　temperature　decreases　to　as　low　as　159　°C.　Besides,　the　HA　paper　with　intrinsic　fire　resistance　ensures　the　structural　integrity　of　ssDNA-DNA　in　the　flame,　contributing　to　the　steady　working　of　the　composite　paper.　This　work　highlights　the　critical　roles　of　biomolecules　and　inorganic　materials　in　synergistically　regulating　fire　warning　performance　of　GO.　©　2023　American　Chemical　Society.