The　emission　of　volatile　organic　compounds　(VOCs)　has　resulted　in　increasingly　severe　harm　to　the　environment　and　human　health.　In　recent　years,　biological　methods　have　become　the　preferred　technology　for　VOC　removal　due　to　their　environmental　friendliness　and　economic　advantages.　Based　on　the　theory　of　bibliometrics,　this　study　analyzed　research　articles　and　reviews　on　biological　methods　for　VOC　removal　published　in　the　Web　of　Science　Core　Collection　(WOSCC)　database　from　1966　to　2021.　The　knowledge　map　visualization　software　CiteSpace　was　utilized　to　analyze　research　progress　in　different　countries,　co-citation　clustering,　co-citation　bursts,　and　keyword　clustering　in　the　literature　data.　The　results　indicated　that　early　research　on　VOC　biological　treatment　focused　on　the　removal　of　odorous　gases　and　single　components　of　volatile　organic　waste　gases.　Subsequently,　benzene　contents　(BTEX),　hydrophobic　VOCs,　and　multi-component　VOCs　have　gradually　become　the　focus　of　research.　In　recent　years,　improving　VOC　removal　efficiency　by　studying　packing　materials　and　microbial　communities　has　become　an　important　research　topic　both　domestically　and　internationally.　Future　research　should　focus　on　continuously　improving　the　performance　of　reactors,　developing　novel　reactors,　and　investigating　technologies　for　treating　complex　and　recalcitrant　VOCs.　©　2023　by　the　authors.