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[期刊论文]

Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect

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author:

Cao, X. (Cao, X..) [1] | Liu, Q. (Liu, Q..) [2] | Shi, W. (Shi, W..) [3] | Unfold

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Scopus

Abstract:

Bisdemethoxycurcumin (BDMC) is the main active ingredient that is isolated from Zingiberaceae plants, wherein it has excellent anti-tumor effects. However, insolubility in water limits its clinical application. Herein, we reported a microfluidic chip device that can load BDMC into the lipid bilayer to form BDMC thermosensitive liposome (BDMC TSL). The natural active ingredient glycyrrhizin was selected as the surfactant to improve solubility of BDMC. Particles of BDMC TSL had small size, homogenous size distribution, and enhanced cultimulative release in vitro. The anti-tumor effect of BDMC TSL on human hepatocellular carcinomas was investigated via 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method, live/dead staining, and flowcytometry. These results showed that the formulated liposome had a strong cancer cell inhibitory, and presented a dose-dependent inhibitory effect on migration. Further mechanistic studies showed that BDMC TSL combined with mild local hyperthermia could significantly upregulate B cell lymphoma 2 associated X protein levels and decrease B cell lymphoma 2 protein levels, thereby inducing cell apoptosis. The BDMC TSL that was fabricated via microfluidic device were decomposed under mild local hyperthermia, which could beneficially enhance the anti-tumor effect of raw insoluble materials and promote translation of liposome. © 2023 Elsevier B.V.

Keyword:

Antitumor Bisdemethoxycurcumin Glycyrrhizin Microfluidic Thermosensitive liposomes

Community:

  • [ 1 ] [Cao X.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 2 ] [Cao X.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 3 ] [Liu Q.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 4 ] [Liu Q.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 5 ] [Shi W.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 6 ] [Shi W.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 7 ] [liu K.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 8 ] [liu K.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 9 ] [Deng T.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 10 ] [Deng T.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 11 ] [Weng X.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 12 ] [Pan S.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 13 ] [Yu Q.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 14 ] [Yu Q.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 15 ] [Deng W.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 16 ] [Deng W.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 17 ] [Yu J.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 18 ] [Yu J.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 19 ] [Wang Q.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 20 ] [Wang Q.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China
  • [ 21 ] [Xiao G.]College of Environment and Safety Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
  • [ 22 ] [Xu X.]Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China
  • [ 23 ] [Xu X.]Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China

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Source :

International Journal of Pharmaceutics

ISSN: 0378-5173

Year: 2023

Volume: 641

5 . 3

JCR@2023

5 . 3 0 0

JCR@2023

ESI HC Threshold:26

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 2

30 Days PV: 0

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