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author:

Zhang, Huizhen (Zhang, Huizhen.) [1] | Lin, Zhiyi (Lin, Zhiyi.) [2] | Li, Yuxuan (Li, Yuxuan.) [3] | Lin, Ziyi (Lin, Ziyi.) [4] | Yang, Shengping (Yang, Shengping.) [5] | Qiu, Bin (Qiu, Bin.) [6] | Yu, Mingdian (Yu, Mingdian.) [7]

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EI

Abstract:

As a dimeric protein, thyroglobulin (Tg) is an important biomarker for different thyroid cancer (DTC), so designing effective method to detect Tg is of great significance. In this work, by preparing β-cyclodextrin (CD) functionalized carbon nanotubes (CNTs) nanohybrid (CD-CNTs) as carrier to immobilize primary antibody (Ab1) of Tg, assembling sulfydryl ferrocene (Fc) and secondary antibody (Ab2) on the surface of nanogold (Au) as signaling amplifier (Ab2-Au-Fc), a simple and sensitive sandwich-type electrochemical immunoassay (STEM) of Tg was designed herein for the first time. In brief, CNTs show large surface area and conductivity, while CD offers superior host–guest recognition capability that can bound with Ab1; meanwhile, Fc probe can offer stable electrochemical signal that is proportionable to the concentration of Tg. Under the optimum conditions, the proposed STEM platform shows excellent sensing results for Tg detection: a considerable low analytical detection (0.5 ng mL−1) and wide linearity (2 to 200 ng mL−1), suggesting the designed STEM platform offers potential real applications for detect Tg. Graphical abstract: [Figure not available: see fulltext.]. © 2023, The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.

Keyword:

Antibodies Carbon nanotubes Chemical detection Diseases Electrochemical sensors Glycoproteins Immunology Immunosensors Iron compounds Organometallics

Community:

  • [ 1 ] [Zhang, Huizhen]Department of B-Mode Ultrasound, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial, Fuzhou; 350001, China
  • [ 2 ] [Lin, Zhiyi]Department of Nuclear Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou; 350001, China
  • [ 3 ] [Li, Yuxuan]Department of Nuclear Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou; 350001, China
  • [ 4 ] [Lin, Ziyi]Department of Nuclear Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou; 350001, China
  • [ 5 ] [Yang, Shengping]Department of Nuclear Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou; 350001, China
  • [ 6 ] [Qiu, Bin]Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology (Fuzhou University), Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fujian, Fuzhou; 350108, China
  • [ 7 ] [Yu, Mingdian]Department of Nuclear Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou; 350001, China

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Source :

Analytical Sciences

ISSN: 0910-6340

Year: 2023

Issue: 6

Volume: 39

Page: 969-975

1 . 8

JCR@2023

1 . 8 0 0

JCR@2023

ESI HC Threshold:39

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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