Due　to　the　great　affinity　and　the　similarity　of　the　physical　performance　of　iron　and　molybdenum　disulfide　in　the　concentrate,　it　is　difficult　to　affect　the　removal　and　separation　of　iron　during　the　procession　of　molybdenum　concentrate.　The　application　of　molybdenum　disulfide　two-dimensional　layered　materials　is　seriously　restricted　by　the　relatively　high　content　of　iron.　Considering　the　direct　purification　of　MoS2,　vacuum　chlorination　roasting　for　decreasing　iron　of　molybdenum　concentrate　is　proposed.　Thermodynamics　of　iron　removal　by　vacuum　chlorination　roasting　is　analyzed.　FeS　can　be　chloridized　into　FeCl2,　which　volatilizes　easily　by　solid　chlorination　agent　in　vacuum.　The　experimental　results　showed　that　the　iron　content　decreased　to　0.43%　at　1223　K　and　P　similar　to　1　Pa　for　60　min,　and　the　Fe　content　was　reduced　to　0.082%　after　acid　washing,　with　a　removal　rate　of　94.2%.　which　offers　a　novel　way　to　replace　the　conventional　method　for　elimination　of　iron　sulfide　in　molybdenum　ore.　Possible　separation　mechanism　of　iron　sulfide　is　also　discussed　in　this　work.