Herein,　the　synergistic　healing　activity　of　treadmill　exercise　and　curcumin-delivering　hydrogel　was　evaluated　in　a　rat　model　of　skeletal　muscle　injury.　In　vitro　experiments　were　utilized　to　characterize　the　filler　material　and　the　healing　potential　of　the　treatment　strategy　was　investigated　in　a　rat　model　of　anterior　tibialis　muscle　injury.　Study　showed　excellent　biocompatibility　of　the　hydrogel　system.　In　vivo　study　showed　that　the　developed　hydrogel　and　treadmill　sport　regimen　significantly　augmented　muscle　function　recovery　as　evidenced　by　histopatholog-ical　analysis.　Gene　expression　studies　showed　that　tissue　expression　levels　of　NFK-B　and　collagen　type　1　genes　were　significantly　downregulated　in　the　animals　treated　with　curcumin-loaded　hydrogels　with　and　without　exercise.