Porous　single　crystals　(PSCs)　have　the　advantages　of　both　long-range　ordered　lattice　structure　and　disordered　connected　pore　structure,　which　can　provide　structural　coherence　and　long-distance　electronic　connectivity,　thus　reducing　the　energy　loss　at　grain　boundaries　and　maintaining　high　stability　and　activity.　In　our　work,　we　prepared　PSCs　Mn2O3,　Mn3O4　and　MnO　and　loaded　cobalt　on　these　PSCs　by　impregnation　to　test　the　catalytic　performance　of　CO　oxidation.　The　results　show　that　all　PSC　manganese　oxides　loaded　with　cobalt　can　maintain　good　performance　and　cobalt-loaded　PSC　MnO　can　completely　oxidize　CO　at　170　degrees　C.　In　the　case　of　fully　adsorbed　1%　CO,　the　proportion　of　oxygen　species　adsorbed　on　the　surface　becomes　the　key　factor　determining　the　reaction　performance.　Among　them,　Mn2O3　loaded　with　cobalt　can　maintain　long-term　stability　for　127　h　without　attenuation.　Furthermore,　all　cobalt-loaded　manganese　oxides　can　complete　30　catalytic　cycles.　This　work　provides　an　idea　for　the　design　of　PSCs　and　gives　a　reference　for　the　study　of　CO　oxidation　in　the　field　of　non-noble　metals.