Under　the　flotation　system　of　dodecylamine　collector,　the　effects　of　acetylacetone　on　desilication　and　decalcification　from　magnesite　by　one-step　reverse　flotation　were　investigated　through　the　flotation　test　of　single　mineral　and　artificial　mixed　ore.　The　mechanisms　of　acetylacetone　on　flotation　desilication　and　decalcification　of　magnesite　were　discussed　through　the　analysis　of　mineral　surface　Zeta　potential　and　infrared　spectra　before　and　after　the　action　of　reagent.　The　results　show　that　acetylacetone　has　a　certain　inhibitory　effect　on　magnesite,　but　has　no　obvious　effect　on　dolomite　and　quartz.　Acetylacetone　has　a　good　separation　effect　on　reverse　flotation　desilication　and　decalcification　of　magnesite.　Acetylacetone　forms　more　magnesium　containing　complexes　on　the　surface　of　magnesite　than　on　the　surface　of　dolomite.　The　adsorption　capacity　is　large　and　stable,　which　enhances　the　positive　electricity　of　the　mineral　surface,　and　is　not　conducive　to　the　adsorption　of　collector　dodecylamine　on　the　surface　of　magnesite,　resulting　in　strong　inhibition　of　magnesite.　Acetylacetone　hardly　adsorbs　on　the　surface　of　quartz,　it　does　not　affect　the　adsorption　of　dodecylamine　on　the　surface　of　quartz.　©　2022,　China　Science　Publishing　&　Media　Ltd.　All　right　reserved.