Tonalid,　an　important　fragrance　ingredient　with　widespread　application,　was　synthesized　via　two　Friedel-Crafts　reactions,　which　were　catalyzed　by　AlCl3.　The　traditional　tonalid　production　was　conducted　in　batch　stirring　tank　reactors,　suffering　from　low　production　capacity　and　the　safety　hazard　of　temperature　runaway.　To　solve　these　problems,　the　continuous-flow　technologies　were　developed　for　the　high-efficiency　and　intrinsically　safe　synthesis　of　tonalid　in　microreactors.　Catalyst　AlCl3　was　neatly　homogenized　in　proper　solvents　by　forming　complex　with　reactant,　which　was　a　necessary　step　for　the　continuous　synthesis　in　microreactors.　Several　reaction　conditions,　including　reactant　molar　ratio,　catalyst　concentration,　temperature,　and　microchannel　hydrodynamic　diameter,　were　investigated　for　the　two　Friedel-Crafts　reactions　in　microreactors.　At　optimized　conditions,　the　yields　of　the　two　Friedel-Crafts　reactions　were　44.15%　and　97.55%,　respectively.　In　comparison　with　the　batch　reactors,　the　reaction　times　of　these　two　reactions　could　both　be　reduced　by　nearly　two　thirds　in　microreactors　at　the　similar　yield.　©　2021　The　Chemical　Industry　and　Engineering　Society　of　China,　and　Chemical　Industry　Press　Co.,　Ltd