Gold　nanoparticles　with　large　size　exhibit　preferable　properties　for　photothermal　therapy　(PTT).　However,　the　prolonged　tissue　retention　and　slow　elimination　of　gold　nanoparticles　limit　their　therapeutic　applications.　Previously,　gold　nanoclusters　carrying　lipid　nanoparticles　(Au-LNPs)　have　been　reported　after　simply　mixing　Au3+　with　preformed　diethylenetriaminepentaacetic　acid　lipid　nanoparticles　to　solve　this　contradiction.　Au-LNPs　demonstrated　enhanced　photothermal　effects　in　comparison　to　neat　gold　nanoparticles.　To　further　improve　the　photothermal　activity,　we　introduced　the　organic　photothermal　agent　boron　dipyrromethene　(BODIPY)　to　Au-LNPs　for　synergistic　PTT.　Au　and　BODIPY-grafted　LNPs　(AB-LNPs)　were　formed　by　simply　mixing　Au-LNPs　with　BODIPY.　The　BODIPY　could　be　associated　stably　to　Au-LNPs,　and　the　release　of　BODIPY　from　AB-LNPs　could　be　accelerated　by　laser　irradiation.　AB-LNPs　are　scalable　and　showed　excellent　photothermal　effects.　AB-LNPs　showed　enhanced　cellular　uptake　efficiency　compared　to　free　BODIPY　in　4T1　breast　cancer　cells.　Under　laser　irradiation,　AB-LNPs　exhibited　synergistic　photothermal　effects　with　significantly　reduced　dosage　compared　to　monotherapy　(treatments　with　Au-LNPs　or　free　BODIPY　alone).　This　study　thus　provides　a　facile　and　adaptive　strategy　for　the　development　of　a　scalable　and　safe　high-performance　nanoplatform　for　synergistic　PTT　in　the　treatment　of　cancer　and　other　diseases.　©　2022　Wang　et　al.;　licensee　Beilstein-Institut.　License　and　terms:　see　end　of　document.