The　leaked　hazardous　chemicals　pose　significant　risks　due　to　their　harmful　and　combustible　nature.　Removing　them　from　the　environment　has　become　an　arduous　task　for　both　the　industrial　sector　and　academic　community.　In　this　paper,　Ti3C2Tx　(MXene)　nanosheets　and　metal-organic　framework　(ZIF-8　MOFs)　functionalized　polyurethane　(PU)　sponges　(PU-Ti3C2Tx-MOF　sponges)　were　prepared　by　immersion　coating　and　in-situ　growth　techniques.　The　as-prepared　PU-Ti3C2Tx-MOF　sponge　exhibited　superior　hydrophobicity　with　a　water　contact　angle　of　135°.　Additionally,　it　demonstrated　a　higher　adsorption　capacity　and　rapid　adsorption　ability　for　liquid　hazardous　chemicals　within　1　min,　while　still　maintaining　good　reusability　for　adsorption.　The　PU-Ti3C2Tx-MOF2　sponge　had　the　highest　adsorption　capacity　of　48–91　times　of　its　own　mass　for　liquid　hazardous　chemicals.　Furthermore,　it　demonstrated　excellent　reusability,　maintaining　its　high　adsorption　capacity　for　oils　and　organic　solvents　even　after　being　used　5　times.　These　results　surpass　previously　reported　data　and　highlight　the　superior　capabilities　of　the　PU-Ti3C2Tx-MOF2　sponge.　Meanwhile,　the　PU-Ti3C2Tx-MOF　sponge　maintained　the　excellent　flame　retardancy　and　compressibility.　This　work　provides　a　new　pathway　for　the　design　of　functional　polymer　sponges　and　their　potential　application　in　rapid　elimination　of　the　leaked　hazardous　chemicals.　©　2023　Elsevier　Ltd