In　chemical　engineering,　the　Fischer–Speier　esterification　shows　incredible　value　for　biofuel　production.　However,　the　transformation　suffers　from　challenges　including　necessary　catalysts　that　cause　corrosion　issues　in　addition　to　a　complex　synthesis.　Herein,　we　report　a　green　acidic　liquid,　[N,N,N-tris(propanesulfonic)aniline][ethanol]3,　which　is　induced　by　hydrogen　bonding　interactions　between　a　hydrogen　bond　acceptor　(HBA)　of　[N,N,N-tris(propanesulfonic)aniline]　and　three　hydrogen　bond　donators　(HBD)　of　ethanol,　through　a　one-step　reaction.　This　liquid　demonstrates　strong　Bronsted　acidity　and　hydrogen　bond　networking　to　mimic　ionic　liquids　(ILs)　or　deep-eutectic　solvents　(DESs).　Even　under　mild　conditions,　biodiesel　was　produced　with　97.65%　of　esterification　conversion.　Exploiting　distinguished　molecular　geometry　with　a　singular　methodology,　made　possible　by　contributions　from　HBD,　allows　for　a　further　reaction　of　1,3-propanesulfonate　with　positively　charged　amines.　This　discovery　is　feasible　with　a　wide　range　of　HBDs　as　a　solvent　resulting　more　commercially　accessible　products　owing　to　a　much　greener　synthesis　when　compared　with　ILs　and　DESs.　©　2023　American　Institute　of　Chemical　Engineers.