The　prediction　system　EpiSIX　was　used　to　study　the　COVID-19　epidemic　in　mainland　China　between　November　2022　and　January　2023,　based　on　reported　data　from　December　9,　2022,　to　January　30,　2023,　released　by　The　Chinese　Center　for　Disease　Control　and　Prevention　on　February　1,　2023.　Three　kinds　of　reported　data　were　used　for　model　fitting:　the　daily　numbers　of　positive　nucleic　acid　tests　and　deaths,　and　the　daily　number　of　hospital　beds　taken　by　COVID-19　patients.　It　was　estimated　that　the　overall　infection　rate　was　87.54%　and　the　overall　case　fatality　rate　was　0.078%–0.116%　(median　0.100%).　Assuming　that　a　new　COVID-19　epidemic　outbreak　would　start　in　March　or　April　of　2023,　induced　by　a　slightly　more　infectious　mutant　strain,　we　predicted　a　possible　large　rebound　between　September　and　October　2023,　with　a　peak　demand　of　between　800,000　and　900,000　inpatient　beds.　If　no　such　new　outbreak　was　induced　by　other　variants,　then　the　current　COVID-19　epidemic　course　in　mainland　China　would　remain　under　control　until　the　end　of　2023.　However,　it　is　suggested　that　the　necessary　medical　resources　be　prepared　to　manage　possible　COVID-19　epidemic　emergencies　in　the　near　future,　especially　for　the　period　between　September　and　October　2023.　©　2023