Arylation of Terminal Alkynes: Transition-Metal-Free Sonogashira-Type Coupling for the Construction of C(sp)-C(sp2) Bonds - Details

author：

Indexed by：

Scopus

Abstract：

Alkynes　are　attractive　synthons　for　organic　chemistry.　Despite　the　prevalence　of　transition-metal-catalyzed　Sonogashira　reactions,　a　transition-metal-free　version　of　the　arylation　of　terminal　alkynes　is　elusive.　Herein,　we　report　an　efficient　transition-metal-free　Sonogashira-type　coupling　reaction　for　the　one-pot　arylation　of　alkynes　to　construct　C(sp)-C(sp2)　bonds　from　a　tetracoordinate　boron　intermediate　with　NIS　as　a　mediator.　With　its　high　efficiency,　wide　substrate　range,　and　good　functional　group　tolerance,　this　method　is　further　supported　by　the　gram-scale　synthesis　and　subsequent　modification　of　complex　molecules.　©　2023　American　Chemical　Society.

Keyword：

Community：

[ 1 ] [Ye, M.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 2 ] [Hou, M.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 3 ] [Wang, Y.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 4 ] [Ma, X.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 5 ] [Yang, K.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 6 ] [Song, Q.]Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fujian, Fuzhou, 350108, China
[ 7 ] [Song, Q.]School of Chemistry and Chemical Engineering, Henan Normal University, Henan, Xinxiang, 453007, China

Reprint 's Address：

[Song, Q.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian, China

Email：

qsong@hqu.edu.cn

Show more details

Related Keywords：

Source ：

Organic Letters

ISSN： 1523-7060

Year： 2023

Issue： 10

Volume： 25

Page： 1787-1792

4 . 9

JCR@2023

4 . 9 0 0

JCR@2023

ESI HC Threshold：39

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 7

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to