Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo - Details

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We　developed　a　circular　bivalent　aptamer　(CBA)　to　precisely　activate　membrane　receptor-mediated　regenerative　signaling　for　liver　repair　in　vivo.　The　CBA　showed　enhanced　biostability　and　receptor　binding　avidity,　achieving　effective　pathway　activation　and　satisfactory　treatment　in　an　acetaminophen-induced　liver　injury　model.　This　work　expands　aptamer-based　molecular　engineering　in　regenerative　medicine.　©　2023　The　Royal　Society　of　Chemistry.

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Chemical activation Diseases

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[ 1 ] [Liang, Hong]College of Geography and Oceanography, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou; 350108, China
[ 2 ] [Yan, Zhike]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 3 ] [Tong, Yuhong]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 4 ] [Chen, Shan]College of Geography and Oceanography, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou; 350108, China
[ 5 ] [Li, Jingying]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 6 ] [Chen, Lanlan]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
[ 7 ] [Yang, Huanghao]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350108, China

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Source ：

Chemical Communications

ISSN： 1359-7345

Year： 2023

Issue： 12

Volume： 59

Page： 1621-1624

4 . 3

JCR@2023

4 . 3 0 0

JCR@2023

ESI HC Threshold：39

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 8

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 8

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