The　Pt-Sn/Al2O3　catalyst　has　been　successfully　commercialized　for　propane　dehydrogenation,　but　it　is　still　highly　desirable　to　further　improve　its　catalytic　performance　for　maximizing　the　utilization　efficiency　of　noble　metal　Pt.　Herein,　this　work　demonstrates　that　doping　Nb　and　Ta　into　Pt-Sn/Al2O3　has　great　impacts　on　its　structure,　and　significantly　improved　catalytic　performances　are　achieved　in　Pt-Sn-X/Al2O3(X=Nb　and　Ta).　It　is　found　that　the　incorporation　of　Nb　and　Ta　into　Pt-Sn/Al2O3　can　promote　the　dispersion　of　Pt-Sn　particles,　which　results　in　Pt-Sn　clusters　being　highly　dispersed　at　the　surface　of　Al2O3.　Moreover,　the　presence　of　Nb　and　Ta　makes　the　SnOx　species　less　reducible,　and　thus　the　Pt-Sn　particles　become　more　stable　at　high　temperature.　Systematic　exploration　allows　to　obtain　the　optimized　Pt-Sn-Nb-5.0/Al2O3　and　Pt-Sn-Ta-1.0/Al2O3,　and　these　two　catalysts　exhibit　high　initial　propane　conversion　(above　43.8　%　and　50.4　%)　with　propylene　selectivity　of　above　98　%.　Most　importantly,　they　show　excellent　regeneration　in　propane　dehydrogenation,　and　their　catalytic　performance　can　be　completely　restored　by　a　simple　calcination.