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author:

Pan, Lin (Pan, Lin.) [1] (Scholars:潘林) | He, Tian (He, Tian.) [2] | Huang, Zihan (Huang, Zihan.) [3] | Chen, Shuai (Chen, Shuai.) [4] | Zhang, Junrong (Zhang, Junrong.) [5] | Zheng, Shaohua (Zheng, Shaohua.) [6] (Scholars:郑绍华) | Chen, Xianqiang (Chen, Xianqiang.) [7]

Indexed by:

Scopus SCIE

Abstract:

Objectives Patients with T4 obstructive colorectal cancer (OCC) have a high mortality rate. Therefore, an accurate distinction between T4 and T1-T3 (NT4) in OCC is an important part of preoperative evaluation, especially in the emergency setting. This paper introduces three models of radiomics, deep learning, and deep learning-based radiomics to identify T4 OCC.Methods We established a dataset of computed tomography (CT) images of 164 patients with pathologically confirmed OCC, from which 2537 slides were extracted. First, since T4 tumors penetrate the bowel wall and involve adjacent organs, we explored whether the peritumoral region contributes to the assessment of T4 OCC. Furthermore, we visualized the radiomics and deep learning features using the t-distributed stochastic neighbor embedding technique (t-SNE). Finally, we built a merged model by fusing radiomic features with deep learning features. In this experiment, the performance of each model was evaluated by the area under the receiver operating characteristic curve (AUC).Results In the test cohort, the AUC values predicted by the radiomics model in the dilated region of interest (dROI) was 0.770. And the AUC value of the deep learning model with the patches extended 20-pixel reached 0.936. Combining the characteristics of radiomics and deep learning, our method achieved an AUC value of 0.947 in the T4 and non-T4 (NT4) classification, and increased the AUC value to 0.950 after the addition of clinical features.Conclusion The prediction results of our merged model of deep learning radiomics outperformed the deep learning model and significantly outperformed the radiomics model. The experimental results demonstrate that combining the peritumoral region improves the prediction performance of the radiomics model and the deep learning model.

Keyword:

Deep learning Obstructive colorectal cancer Peritumoral region Radiomics ResNet

Community:

  • [ 1 ] [Pan, Lin]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 2 ] [He, Tian]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 3 ] [Zheng, Shaohua]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China
  • [ 4 ] [Huang, Zihan]Harbin Inst Technol, Sch Future Technol, Harbin 150000, Peoples R China
  • [ 5 ] [Chen, Shuai]Fujian Med Univ Union Hosp, Dept Emergency Surg, Fuzhou 350001, Peoples R China
  • [ 6 ] [Zhang, Junrong]Fujian Med Univ Union Hosp, Dept Emergency Surg, Fuzhou 350001, Peoples R China
  • [ 7 ] [Chen, Xianqiang]Fujian Med Univ Union Hosp, Dept Emergency Surg, Fuzhou 350001, Peoples R China

Reprint 's Address:

  • [Zheng, Shaohua]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Peoples R China;;[Chen, Xianqiang]Fujian Med Univ Union Hosp, Dept Emergency Surg, Fuzhou 350001, Peoples R China;;

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Source :

ABDOMINAL RADIOLOGY

ISSN: 2366-004X

Year: 2023

Issue: 4

Volume: 48

Page: 1246-1259

2 . 3

JCR@2023

2 . 3 0 0

JCR@2023

ESI Discipline: CLINICAL MEDICINE;

ESI HC Threshold:25

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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