To　promote　the　bone　repair　ability　of　drug-loaded　scaffolds,　poly(lactic　acid)　(PLA)/graphene　oxide　(GO)/Salvianolic　acid　B　(Sal-B)/aspirin　(ASA)　dual　drug-loaded　biomimetic　composite　scaffolds　were　prepared.　The　results　showed　that　the　addition　of　these　two　drugs　delayed　the　gel　formation　of　the　composite　system,　but　a　biomimetic　nanofiber　structure　could　still　be　obtained　by　extending　the　gel　time.　The　addition　of　Sal-B　increased　the　hydrophilicity　of　the　scaffold,　while　an　increase　in　ASA　reduced　the　porosity.　Dual　drug-loaded　scaffolds　had　good　haemocompatibility　and　synergically　promoted　the　proliferation　of　MC3T3-E1　cells　and　enhanced　alkaline　phosphatase　activity.　Sustained-release　experiments　of　the　two　drugs　showed　that　the　presence　of　ASA　slowed　the　cumulative　release　of　Sal-B,　while　Sal-B　promoted　the　release　of　ASA.　Kinetic　modeling　showed　that　the　release　of　both　drugs　conforms　to　the　Korsmeyer-Peppas　model,　but　Sal-B　conforms　to　the　Fick　diffusion　mechanism　and　ASA　follows　Fick　diffusion　and　carrier　swelling/dissolution.