A　ring-expansion　reaction　of　2H-azirine　with　trifluoroacetic　anhydride　for　the　synthesis　of　2-(trifluo-romethyl)oxazoles　is　disclosed.　The　reaction　features　readily　available　reactants,　relatively　mild　condi-tions,　and　high　yields　of　products.　The　generated　2-(trifluoromethyl)oxazole　core　could　be　easily　converted　into　3-(trifluoromethyl)-1,2,4-triazines　through　hydrazinolysis　reaction.(c)　2022　Elsevier　Ltd.　All　rights　reserved.