Due　to　the　multiclass　complex　processes　in　the　oxygen　evolution　reaction　(OER)　by　Ni-based　double　hydroxides　(DHs)　electrocatalysts,　it　is　necessary　to　seek　a　comprehensive　assessment　to　uncover　the　electrochemical　nat-ure.　Here,　Ni0.8M0.2　DHs　and　Ni0.7M0.3　DHs　nanowires　(M　=　Zn,　Co,　Fe,　Cu)　were　prepared　by　a　hydrothermal　method.　As　the　intrinsic　chemical　property,　metal　ion　electronegativity　(MIE)　as　the　descriptor,　the　struc-ture-activity　relationship　between　MIE　and　OER　reaction　intermediates＇　adsorption　and　desorption　capacity　was　researched　by　the　electrochemical　impedance　analysis.　At　the　top　of　the　volcano　trend　(MIE　=　1.39,　Ni0.8Co0.2　DHs),　it　is　screened　and　exhibits　the　lowest　interfacial　charge　transfer　resistance　and　the　adsorption　and　desorption　resistance　of　intermediates.　This　work　provides　a　cost-effective　method　based　on　the　theory　of　electronegativity　equilibrium　for　the　precise　screening　and　design　of　high-active　OER　electrocatalysts.