Multi-modal　synergistic　therapy,　especially　the　integration　of　near-infrared　laser　phototherapies　and　chemo-therapy,　is　often　sought　after　owing　to　its　minimal　invasiveness,　low　side　effects,　and　improved　anticancer　therapeutic　efficacy.　Herein,　CuS　nanoparticles　were　first　coated　with　zinc　phthalocya-nine　derivant　(Pc)-functionalized　mesoporous　silica　(mSiO2-Pc)　to　achieve　a　drug　delivery　system　(CuS@mSiO2-Pc)　with　photo-thermal/photodynamic　therapy.　Chemical　drug　DOX　was　subsequently　loaded　for　chemotherapy,　and　hyaluronic　acid　(HA)　was　employed　as　a　covering　material　with　cancer　targeting.　The　as-obtained　CuS@mSiO2-Pc(DOX)@HA　nanoparticles　were　nano-sized　with　good　biocompatibility,　effective　DOX　loading,　and　controllable　DOX　releasing.　Expectedly,　this　multifunctional　nanoplatform　exhibits　effective　generation　of　reactive　oxygen　species　and　hyperthermia　upon　the　near-infrared　laser　irradiation.　Most　importantly,　the　nanoparticles　were　targeted　into　4T1　cells　and　showed　significantly　remarkable　cytotoxicity　under　near　-infrared　laser　irradiation,　proving　their　synergistic　therapeutic　efficacy.　Therefore,　this　targeted　drug　system　based　on　CuS　with　synergistic　photothermal　therapy/photodynamic　therapy/chemotherapy　has　great　application　prospects　in　clinical　anticancer　treatment　for　triple　negative　breast　cancer.