Superoxide　dismutase　(SOD)　is　an　enzyme　found　in　most　food　sources,　might　be　a　candidate　to　reduce　oxidative　damage　to　intestinal　barrier,　thereby　ameliorating　the　vicious　circle　between　hyperglycemia　and　the　oxidative　damage.　Here　we　report　the　oral　administration　of　SOD,　liposome-embedded　SOD　(L-SOD),　and　SOD　hydrolysate　to　type　2　diabetic　model　rats　to　confirm　this　hypothesis.　Oxidative　damage　severity　in　model　rat　intestine　was　indicated　by　malondialdehyde　level,　GSSG/GSH　ratio,　and　antioxidant　enzyme　activity.　The　damage　was　significantly　repaired　by　L-SOD.　Furthermore,　blood　glucose　and　related　indexes　correlated　well　not　only　with　oxidative　damage　results　but　also　with　indexes　indicating　physical　intestinal　damage　such　as　colon　density,　H&E　staining,　immunohistochemical　analysis　of　the　tight　junction　proteins　occludin　and　ZO-1　in　the　colon,　as　well　as　lipopolysaccharide　and　related　inflammatory　cytokine　levels.　The　order　of　the　magnitude　of　the　effects　of　these　SOD　preparations　was　L-SOD　＞　SOD　＞　SOD　hydrolysate.　These　data　indicate　that　orally　administered　SOD　can　exhibit　glucose-lowering　effect　via　targeting　the　intestine　of　diabetic　rats　and　systemic　lipopolysaccharide　influx.　©　2022,　The　Author(s).