The　separation　and　enrichment　of　uranium　from　various　resources　such　as　seawater　is　of　great　significance　to　the　sustainable　development　of　nuclear　energy.　Therefore,　there　is　an　urgent　need　to　develop　an　adsorbent　with　low　cost　and　easy　availability,　simple　preparation　process,　and　environment　friendly.　In　this　work,　we　used　inexpensive　natural　polymer　material　(sodium　alginate)　and　natural　adsorbents　(β-cyclodextrin　and　diatomite)　to　prepare　a　novel　biosorbent　β-cyclodextrin/sodium　alginate/diatomite　(CSD)　hydrogel　beads　for　uranium　adsorption　by　a　simple　method.　The　results　of　FTIR,　XRD,　SEM,　EDX　and　XPS　characterization　proved　that　the　CSD　were　prepared.　Static　adsorption　experiments　showed　that　pH,　contact　time,　initial　concentration　of　U(VI)　and　temperature　has　significant　impact　on　the　adsorption　capacity　of　CSD.　Adsorption　fitted　the　pseudo-second-order　kinetic　model　and　Langmuir　model　and　the　adsorption　mechanism　is　chemical　adsorption.　In　the　presence　of　other　metal　ions　(Cu2+,　Mg2+,　Ca2+,　Na+,　K+),　CSD　has　obvious　selectivity　for　uranium(VI)　adsorption.　In　addition,　the　elution　and　reusability　studies　show　that　CSD　has　excellent　reusability.　Overall,　CSD　is　an　inexpensive,　green　preparation,　efficient,　and　environment　friendly　biosorbent　with　obvious　selectivity　for　U(VI).　It　has　potential　application　in　U(VI)　enrichment　from　seawater　or　salt　lake　water.　©　2022