Synthesis of Trifluoromethylated γ-Lactams through Radical Cascades of N-Cyano Alkenes with CF3SO2Na - Details

author：

Cui, J. (Cui, J..) ^[1] | Tong, Y. (Tong, Y..) ^[2] | Li, Y. (Li, Y..) ^[3]

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Scopus

Abstract：

We　report　herein　a　facile　strategy　to　synthesize　trifluoromethylated　γ-lactams　through　trifluoromethylcarbonylation　of　N-cyano　alkenes　using　readily　available　CF3SO2Na　as　the　CF3radical　source.　A　range　of　trifluoromethyl-containing　γ-lactams　was　obtained　in　good　yields.　This　transition-metal-free　protocol　is　demonstrated　with　mild　conditions,　broad　substrate　scope,　good　functional　group　tolerance,　convenient　reagents,　and　an　easy-to-handle　operating　system.　©　2022　American　Chemical　Society.　All　rights　reserved.

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[ 1 ] [Cui, J.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Tong, Y.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Li, Y.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Li, Y.]Key Laboratory of Molecule Synthesis and Function Discovery, China

Email：

liyi-chem@fzu.edu.cn

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Source ：

Journal of Organic Chemistry

ISSN： 0022-3263

Year： 2022

Issue： 23

Volume： 87

Page： 16090-16098

3 . 6

JCR@2022

3 . 4 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 10

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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