The　aerobic　biotreatment　process　for　the　dual　goals　of　antibiotic　removal　and　ammonia　retainment　for　the　field-return-based　treatment　of　swine　wastewater　was　optimized　by　adding　2-chloro-6-trichloromethylpyridine　(TCMP),　commonly　used　as　a　nitrogen　fertilizer　synergist.　The　results　show　that　the　dosage　of　5–10　mg/L　TCMP　daily　effectively　inhibited　nitrification.　The　COD　and　tetracycline　antibiotics　(TCs)　in　the　absence　of　TCMP　was　removed　by　91%　and　76%,　and　became　87%　and　78%　with　5　mg/L　TCMP　and　83%　and　70%　with　10　mg/L　TCMP,　respectively.　The　removal　efficiency　of　four　TCs　generally　followed　a　decreasing　trend　of　chlortetracycline　(CTC)　＞　doxycycline　(DC)　＞　tetracycline　(TC)　＞　oxytetracycline　(OTC).　A　dosage　of　5　mg/L　TCMP　daily　inhibited　ammonia　nitrification　effectively　and　only　slightly　affected　the　removal　of　conventional　organic　pollutants　and　TCs.　The　contribution　of　volatilization　and　hydrolysis　to　the　removal　of　TCs　was　negligible.　The　overall　removal　efficiency　of　four　TCs　in　removal　pathway　experiments　was　98%,　94%,　97%,　and　96%　for　OTC,　CTC,　DC,　and　TC,　of　which　69%,　41%,　56%,　and　62%　was　contributed　by　absorption,　and　29%,　53%,　41%,　and　34%　was　contributed　by　biodegradation,　respectively.　This　study　may　have　significant　implications　for　the　proper　management　of　livestock　wastewater　intended　to　be　used　as　fertilizers,　which　aims　to　reduce　the　exposure　risk　of　antibiotics　and　preserve　its　nutrient　value.　©　2022　Elsevier　Ltd