This　paper　investigates　growth　of　random　polyhedral　voids　(RPVs)　in　structural　steel,　which　is　a　critical　stage　for　ductile　fracture　of　steel.　An　in-situ　high-resolution　μXCT　experiment　shows　that　most　micro-voids　in　structural　steels　can　be　characterized　by　RPVs.　In　this　study,　a　micromechanical　representative　volume　element　(RVE)　model　containing　an　RPV　was　established　with　periodic　boundary　conditions.　Comparison　of　RPV　growths　with　spherical　and　elliptical　void　growths　was　conducted　for　model　validation.　On　this　basis,　effects　of　geometric　parameters　of　the　RPV　on　void　growth　were　analyzed　through　Python-based　parametric　modeling　in　ABAQUS　with　respect　to　the　aspect　ratio,　orientation,　sphericity,　initial　void　volume　fraction,　respectively.　The　results　found　that　growth　of　the　RPV　decreases　with　an　increasing　initial　aspect　ratio　of　the　RPV.　Growth　of　the　RPV　increases　as　the　initial　sphericity　of　RPV　decreases.　When　the　initial　orientation　of　RPV　tends　to　be　perpendicular　to　the　main　tensile　direction,　a　greater　void　growth　will　be　obtained.　The　initial　volume　fraction　of　RPV　has　a　minor　effect　on　void　growth　compared　with　the　other　geometric　parameters.　For　engineering　application,　accurate　and　simplified　formulae　were　proposed　to　evaluate　growth　of　microscopic　RPVs,　respectively.　©　2022