Antibiotics　are　widely　used　and　ubiquitous　in　the　environment,　which　in　turn　poses　potential　threat　to　human　health.　However,　the　effects　of　agricultural　activities　and　river　input　on　the　fate　and　ecological　risks　of　antibiotics　in　shallow　lake　are　still　poorly　understood.　Surface　water,　overlying　water　and　pore　water,　sediments　and　aquatic　plant　samples　in　the　historical　planting　subarea　(PA),　historical　aquaculture　subarea　(AU),　inflow　subarea　(IW),　discharge　subarea　(DC),　and　conservation　subarea　(CK)　of　Baiyangdian　Lake　were　collected　and　analyzed.　Our　results　revealed　that　the　total　antibiotic　concentrations　ranged　from　85.33　ng/L　to　1631.47　ng/L　in　waters　and　from　66.90　ng/g　to　177.03　ng/g　in　sediments.　Generally,　the　total　antibiotic　concentrations　introduced　by　planting　activity　in　surface　water,　overlying　water　and　sediments　were　higher　and　the　levels　of　total　antibiotics　in　pore　water　were　more　affected　by　river　input.　In　addition,　three　quinolones　(QNs)　and　two　tetracyclines　(TCs)　were　dominant　antibiotics　in　almost　five　subareas.　The　pseudo-partitioning　coefficient　kd(pw)　and　bioaccumulation　factor　(BAF)　of　antibiotics　varied　according　to　the　effects　of　river　input　and　historical　agricultural　activities.　The　ecological　risk　(RQ)　of　antibiotics　from　agricultural　activities　was　higher　than　that　from　river　input.　The　norfloxacin　(NOR)　in　pore　water　showed　high　RQ,　which　contributed　to　a　large　proportion　(>50　%)　of　the　combined　ecological　risks　(∑RQs)　except　for　surface　water.　Therefore,　NOR　should　be　used　as　the　primary　ecological　risk　control　index　for　antibiotic　contamination　management　in　the　BYD.　∑RQs　showed　high　risk　in　water　in　the　five　subareas.　This　study　can　act　as　a　reference　for　governments　to　formulate　effective　management　strategies　for　protecting　the　ecological　health　of　lakes.　©　2022　Elsevier　B.V.