Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Xu, Y. (Xu, Y..) [1] | Zhou, C. (Zhou, C..) [2] | Li, D. (Li, D..) [3] | Guo, C. (Guo, C..) [4] | Li, Z. (Li, Z..) [5] | Xing, X. (Xing, X..) [6] | Li, S. (Li, S..) [7] | Guan, T. (Guan, T..) [8] | Liu, L. (Liu, L..) [9] | He, Y. (He, Y..) [10]

Indexed by：

Scopus

Abstract：

In　this　study,　an　aptamer　biosensor　based　on　weak　value　amplification　is　proposed　for　the　first　time.　The　feasibility,　selectivity,　robustness,　and　high　detection　accuracy　of　aptamer　sensors　are　verified　by　the　adenosine　triphosphate　(ATP)　detection　experiment.　The　weak　measurement　system　shows　high　sensitivity　to　phase　changes,　corresponding　to　refractive　index　changes,　attributed　to　the　changes　in　the　spatial　configuration　of　the　aptamer　nucleic　acid　chain　after　specifically　capturing　the　target　molecule.　As　the　main　energy　source　in　the　body,　ATP　plays　an　important　role　in　many　biological　processes,　and　its　detection　is　of　great　significance　to　study　cell　metabolism,　biochemical　pathways,　and　early-stage　disease　diagnosis.　This　work　provides　a　new　labeling-free　detection　scheme　for　aptamer　sensors　and　offers　a　high-precision　and　specific　detection　of　small　biological　molecules　based　on　weak　measurement　biosensors.　The　proposed　method　is　of　great　significance　to　the　development　of　aptamer　sensors　and　weak　value　amplification　technology.　©　2022　Elsevier　B.V.

Keyword：

Adenosine triphosphate detection Aptamer biosensor Lable-free Weak value amplification

Community：

  • [ 1 ] [Xu, Y.]Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 2 ] [Xu, Y.]Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 3 ] [Zhou, C.]Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 4 ] [Zhou, C.]Department of Physics, Tsinghua University, Beijing, 100084, China
  • [ 5 ] [Li, D.]Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
  • [ 6 ] [Guo, C.]School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350108, China
  • [ 7 ] [Li, Z.]Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 8 ] [Li, Z.]Department of Physics, Tsinghua University, Beijing, 100084, China
  • [ 9 ] [Xing, X.]Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 10 ] [Li, S.]Biomedical Engineering Laboratory, School of Information Engineering, Guangdong Medical University, Dongguan, 523808, China
  • [ 11 ] [Guan, T.]Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 12 ] [Guan, T.]School of Medicine, Tsinghua University, Beijing, 100084, China
  • [ 13 ] [Liu, L.]Institute of Materials Research, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 14 ] [He, Y.]Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China
  • [ 15 ] [He, Y.]Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China

Reprint 's Address：

  • [Guan, T.]Tsinghua Shenzhen International Graduate School, China

Email：


guantian@sz.tsinghua.edu.cn
Show more details

Related Keywords：

Related Article：

Source ：

Sensors and Actuators B: Chemical

ISSN： 0925-4005

Year： 2022

Volume： 371

6 . 3 9 3

JCR@2018

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 7

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：8/10042703
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1