Microenvironment-Tailored Catalytic Nanoprobe for Ratiometric NIR-II Fluorescence/Photoacoustic Imaging of H2O2 in Tumor and Lymphatic Metastasis - Details

author：

Indexed by：

Scopus

Abstract：

In　vivo　H2O2　visualization　is　crucial　for　disease　diagnosis.　Catalytic　reaction-based　probes　show　potential　in　H2O2　detection,　yet　their　in　vivo　application　remains　challenging　because　catalysts　always　require　a　specific　pH　to　function　and　cellular　glutathione　(GSH)　may　suppress　signaling　by　depletion　of　hydroxyl　radicals　and　oxidized　substrates.　Here,　a　microenvironment-tailored　catalytic　nanoprobe　(MTCN)　comprising　Fe2+,　citric　acid　(CA),　2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic　acid)　diammonium　salt　(ABTS),　and　downconversion　nanoparticles　in　the　liposomal　cavity　as　well　as　a　reference　dye　in　the　lipid　membrane　is　reported,　which　utilizes　the　selective　permeability　of　the　liposomal　membrane　to　offer　a　favorable　pH　for　Fe2+　catalyst　with　the　aid　of　CA　and　to　avoid　GSH-triggered　signal　loss　by　preventing　entry　of　GSH　into　the　cavity.　The　MTCN　displays　a　large　NIR-II　fluorescence　(FL)　ratio　between　1550　and　1080 nm　(FL1550Em,808Ex/FL1080Em,980Ex),　but　a　small　photoacoustic　(PA)　ratio　between　808　and　1048 nm　(PA808/PA1048).　Upon　exposure　of　MTCN　to　H2O2,　catalytic　conversion　of　ABTS　into　its　oxidized　form　ABTS·+　with　808 nm　absorption　causes　a　noticeable　increment　in　PA808/PA1048　accompanied　by　an　apparent　decrement　in　FL1550Em,808Ex/FL1080Em,980Ex,　enabling　bimodal　ratiometric　imaging　of　H2O2　in　the　tumor　and　lymphatic　metastasis.　©　2022　Wiley-VCH　GmbH.

Keyword：

catalytic nanoprobes hydrogen peroxide NIR-II fluorescence photoacoustic imaging ratiometric imaging

Community：

[ 1 ] [Chen, T.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Chen, Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Zhou, Q.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Ding, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Gong, P.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Wang, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Cai, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Ao, R.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Yu, M.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Song, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 11 ] [Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 12 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, China;;[Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, China

Email：

lisen.lin@fzu.edu.cn |
hhyang@fzu.edu.cn

Show more details

Related Keywords：

Microenvironment-Tailored Catalytic Nanoprobe for Ratiometric NIR-II Fluorescence/Photoacoustic Imaging of H2O2 in Tumor and Lymphatic Metastasis
2022，ADVANCED FUNCTIONAL MATERIALS
Redox-Active Ferrocene Quencher-Based Supramolecular Nanomedicine for NIR-II Fluorescence-Monitored Chemodynamic Therapy
2024，ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Plasmonic-Fluorescent Janus Ag/Ag2S Nanoparticles for In Situ H2O2-Activated NIR-II Fluorescence Imaging
2021，NANO LETTERS
Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies
2020，NANO RESEARCH
A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species
2023，ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Source ：

Advanced Functional Materials

ISSN： 1616-301X

Year： 2022

Issue： 47

Volume： 32

1 9 . 0

JCR@2022

1 8 . 5 0 0

JCR@2023

ESI HC Threshold：91

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to