Phototherapy　has　been　a　promising　therapeutic　modality　for　pathological　tissue　due　to　its　spatiotemporal　selectivity　and　non-invasive　characteristics.　However,　as　a　core　component　of　phototherapy,　a　single　photosensitizer　(PS)　nanoplatform　integrating　excellent　therapeutic　efficiency　and　minimal　side　effects　remains　an　urgent　but　unmet　need.　Here,　we　construct　a　J-aggregated　nano-porphyrin　termed　MTE　based　on　the　self-assembly　of　methyl-pheophorbide　a　derivative　MPa-TEG　(MT)　and　natural　polyphenolic　compound　epigallocatechin　gallate　(EGCG).　Due　to　the　synergistic　interaction　between　similar　large　π-conjugated　structural　EGCG　and　MT,　MTE　with　small　and　uniform　size　is　obtained　by　effectively　hindering　Ostwald　ripening　of　MT.　Noteworthily,　MTE　not　only　effectively　avoids　the　inadvertent　side　effects　of　phototoxicity　during　transport　thank　to　the　ability　of　reactive　oxygen　species　(ROS)　scavenging,　but　also　achieves　two-pathway　augmented　superior　phototherapy:　(1)　enhancing　photodynamic　therapy　(PDT)　via　inhibiting　the　expression　of　anti-apoptosis　protein　surviving;　(2)　achieving　adjuvant　mild-temperature　laser　interstitial　thermal　therapy　(LITT)　via　reducing　the　tumor　thermoresistance　on　account　that　MTE　inhibits　the　overexpression　of　HSP　70　and　HSP　90.　This　research　not　only　offers　a　facile　strategy　to　construct　multicomponent　nanoplatforms　but　also　provides　a　new　pathway　for　efficient　and　low-toxicity　phototherapy,　which　is　beneficial　to　the　future　clinical　application.　©　2022　The　Royal　Society　of　Chemistry.