Biomimetic　scaffolds　loaded　with　drugs　can　improve　the　osteogenesis　and　neovascularisation　of　scaffolds.　A　series　of　PLA/GO/Sal-B　drug-loaded　scaffolds　was　prepared　by　thermally　induced　phase　separation.　The　addition　of　Sal-B　increased　the　diameter　of　the　fibres,　but　the　scaffold　showed　a　porous　nanofibrous　structure　after　drug　release.　X-ray　diffraction　results　showed　that　the　addition　of　Sal-B　did　not　affect　the　formation　of　the　nanofibre　biomimetic　structure　of　the　scaffold.　FTIR　results　indicated　a　certain　interaction　between　Sal-B　and　PLA/GO.　Water　absorption　and　porosity　test　results　revealed　that　the　scaffolds　had　good　hydrophilicity　and　appropriate　porosity.　The　addition　of　Sal-B　was　also　conducive　to　the　formation　of　sediments　possibly　due　to　the　good　water　solubility　of　Sal-B　itself.　The　prepared　scaffolds　had　good　blood　compatibility　and　cytocompatibility,　and　a　small　additional　amount　of　Sal-B　could　significantly　promote　cell　proliferation　and　alkaline　phosphatase　activity.　Their　sustained　release　performance　indicated　that　the　biomimetic　scaffolds　had　controlled　the　release　of　Sal-B.　The　kinetic　model　showed　that　the　PLA/GO/Sal-B　drug-loaded　biomimetic　scaffolds　followed　the　diffusion　mechanism.　©　2022　The　Royal　Society　of　Chemistry.