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Abstract:
An efficient protocol was proposed for the preparation of secondary alcohols in good to excellent yields via photoredoxcatalyzed decarboxylative couplings between readily available arylacetic acids and a variety of less reactive (hetero)aromatic aldehydes. The formation of carbanion is the key intermediate in this reaction. Various substituted arylacetic acids and aldehydes were all compatible with this transformation under mild reaction conditions. Furthermore, the current protocol was successfully applied to the direct alcoholization of several drug acids.
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JOURNAL OF ORGANIC CHEMISTRY
ISSN: 0022-3263
Year: 2022
3 . 6
JCR@2022
3 . 4 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:74
JCR Journal Grade:1
CAS Journal Grade:2
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ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 0
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