Effects　of　vitamin　C　supplementation　on　the　oral　bioaccessibility　of　lead　(Pb)　present　in　contaminated　soils　were　examined　using　a　number　of　in　vitro　assays　(PBET,　SBRC,　UBM　and　IVG).　In　the　presence　of　vitamin　C,　an　increase　in　Pb　bioaccessibility　was　observed　in　the　gastric　phase　by　1.3-fold　(30.5%-85.5%)　and　in　the　intestinal　phase　by　3.1-fold　(0.9%-58.9%).　Lead　mobilization　was　regulated　by　reductive　dissolution　of　Fe(III)　and　sequestration　of　Pb　on　secondary　Fe　minerals.　Sequential　extraction　by　the　Bureau　Community　of　Reference　(BCR)　provided　more　evidence　that　reducible　fraction　and　residual　fraction　were　major　contributor　of　gastric　Pb　bioaccessibility,　as　well　as　reduced　fractions　in　intestinal　Pb　bioaccessibility.　In　addition,　higher　non-carcinogenic　risks　may　occur　based　on　target　hazard　quotient　(THQ　＞=　1).　For　people　exposed　to　Pb　present　in　soil,　the　management　of　vitamin　C　supplements　is　of　serious　concern.