It　is　known　that　biomolecules　are　physiologically　significant　in　controlling　homeostasis.　Any　deviation　in　homeostasis　is　often　detected　by　a　change　in　the　concentrations　of　these　biomolecules.　Hence,　these　biomolecules　are　often　referred　to　as　biomarkers　and　its　accurate　detection　is　of　significant　importance　in　clinical　diagnosis.　Electrochemical　sensing　is　a　well-known,　simple,　cost-effective　and　convenient　method　to　detect　various　biomolecules,　that　also　includes　an　excellent　potential　for　the　miniaturization　of　healthcare　devices.　Metal-organic　frameworks　(MOFs)　are　a　recent　emerging　class　of　materials　that　are　self-assembled　porous　network　structured　architectures　of　organic　linkers　connecting　metal　nodes.　Therefore,　MOFs　are　potential　candidates　to　be　effectively　utilized　as　electrochemical　sensors　to　detect　the　biomolecules　due　to　their　large　surface　area,　controlled　diverse　pore　structure,　enhanced　functionality　and　unique　catalytic　activity.　This　review　covers　the　various　properties　and　notable　approaches　for　functionalizing　MOFs.　Based　on　these　aspects,　a　systematic　and　comprehensive　overview　of　MOF-based　research　for　selective　electrochemical　sensing　of　physiologically　important　biomolecules　is　the　main　focus　of　this　review.　©　2022　Elsevier　B.V.