Leakage　is　a　common　complication　of　surgeries　and　injuries,　causing　pain　and　increasing　the　economic　burden　on　patients.　Although　there　are　commercially　available　sealants　for　leakage　prevention,　few　of　them　are　entirely　satisfactory　due　to　disease　transmission,　high　cost,　and　poor　biocompatibility.　In　addition,　none　of　them　can　be　controllably　removed　for　further　healthcare.　In　this　paper,　by　using　cohesion　design,　a　sealant　based　on　amino-modified　gelatin　(AG)　and　bi-polyethylene　glycol　N-hydroxysuccinimide　active　ester　(Bi-PEG-SS)　was　fabricated.　To　increase　the　bursting　pressure,　the　cohesion　strength　was　enhanced　by　increasing　the　cross-linking　density　of　the　sealant.　To　endow　the　sealant　with　controllably　dissolvable　properties,　the　smart　succinic　ester　units　were　introduced　into　the　cohesion　network.　Both　the　in　vitro　and　in　vivo　experiments　showed　that　this　sealant　processed　high　bursting　pressure　with　efficient　hemorrhage　control.　Moreover,　no　side　effects　were　observed　after　7　days　of　in　vivo　sealing,　including　little　inflammation　and　fibrogenesis.　These　results,　together　with　the　easy　availability　of　the　raw　materials,　revealed　that　this　sealant　might　be　a　promising　alternative　for　leakage　sealing.　©　2022　American　Chemical　Society.