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author:

Xu, Xin (Xu, Xin.) [1] | Jiang, Yifan (Jiang, Yifan.) [2] | Lu, Chunhua (Lu, Chunhua.) [3] (Scholars:卢春华)

Indexed by:

EI SCIE

Abstract:

Tumor marker-responsive drug delivery systems have been developed for cancer imaging and chemotherapy. However, improving their ability of controlled drug release remains a challenge. In this study, we have developed an adenosine triphosphate (ATP)-responsive DNA nanohydrogel for specifically activated fluorescence imaging and chemotherapy in cancer cells. Acrylamide and acrydite-modified DNAs were polymerized to obtain DNA-grafted polyacrylamide copolymers. Then, the copolymers acted as the backbone of the nanohydrogel and were assembled by base complementation with ATP aptamer linkers to construct an ATP-responsive nanohydrogel. Meanwhile, the chemotherapeutic drug doxorubicin (DOX) was added and loaded into the ATP-responsive nanohydrogel during the assembly process. After endocytosis by cancer cells and response to a high intracellular ATP level, the DOX-loaded nanohydrogel disassembled due to the formation of aptamer/ATP complexes. Subsequently, the released DOX played a role in fluorescence imaging and chemotherapy of cancer cells. Through the ATP-responsive property and satisfying drug delivery capability, this nanohydrogel realized fluorescence imaging and specific cancer cell killing capabilities due to different intracellular ATP levels in normal and cancer cell lines. In summary, this study has provided a novel strategy of constructing a tumor microenvironmentresponsive drug delivery system triggered by the tumor markers for tumor intracellular imaging and chemotherapy.

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Community:

  • [ 1 ] [Xu, Xin]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Peoples R China
  • [ 2 ] [Jiang, Yifan]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Peoples R China
  • [ 3 ] [Lu, Chunhua]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Peoples R China

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Source :

ANALYTICAL CHEMISTRY

ISSN: 0003-2700

Year: 2022

7 . 4

JCR@2022

6 . 8 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:74

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 25

SCOPUS Cited Count: 20

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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